TNF-derived peptides for use in treating oedema

Peptides TNF-dérivés pour le traitement des oedémes

TNF-Peptide und deren Verwendung zur Behandlung von Ödemen

Abstract

The present invention relates to the finding that peptides derived from a specific domain of tumor necrosis factor-alpha (TNF-α) can efficiently be used to treat oedema. More specifically, the present invention relates to the usage of peptides derived from the region of human TNF-α from Ser 100 to Glu 116 to treat pulmonary oedema. Moreover, the present invention concerns a circularized peptide having amino acid sequence CGQRETPEGAEAKPWYC which is very efficient in inducing oedema resolution.

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NO-Patent Citations (1)

    Title
    LUCAS R ET AL: "Mapping the lectin-like activity of tumor necrosis factor", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 263, 11 February 1994 (1994-02-11), pages 814 - 817, XP002094772, ISSN: 0036-8075

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