Pteridinderivate als NO Synthase-Hemmer

Pteridinderivatives as NO synthase inhibitors

Des dérivés de ptéridin comme inhibiteur de NO synthase

Abstract

New dihydropteridine derivatives (I). Pteridine derivatives of formula (I) and their tautomers, stereoisomers and salts are new. R1-R4 = H or OH; R5 = H, CH3, CH2OH, 1-9C alkyl, (CH(OH))n-Y or (CH(OH))n-(CH2)m-W; Y = H or lower alkyl; W = H or OH; n, m = 1-20.
Pteridinderivat der Formel wobei R 1 , R 2 , R 3 , R 4 unabhängig voneinander für H oder OH stehen, R 5 für H, CH 3 , CH 2 OH oder einen niederen Alkylrest (C1 bis C9) steht, der geradkettig oder verzweigt sein kann, sowie für (CH(OH)) n -Y oder (CH(OH)) n -(CH 2 ) m -W, wobei Y Wasserstoff oder ein niederer Alkylrest, W ein Wasserstoff oder eine Hydroxylgruppe ist, und n und m unabhängig voneinander 1-20 sind, sowie tautomere und stereoisomere Formen von (I) und deren Salze.

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Patent Citations (3)

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