Composition containing hematopoiesis inhibitor

Composition contenant un inhibiteur d'hematopoiese

Inhibitor der blutbildung enthaltende zusammensetzung

Abstract

A composition containing a hematopoiesis inhibitor that inhibits CFU-E colony formation and comprising a substance present in the filtrate obtained by concentrating a dialyzate, obtained by dialyzing blood through a dialysis membrane having an albumin sieving coefficient of 0.01 or above, with a membrane having a fractionating molecular weight of 5,000 or less and then filtering the concentrate with a gel having a maximum fractionating molecular weight ranging from 0.2 to 1.5 million. The invention also relates to a method of treating blood characterized by removing an A I component so as to satisfy the following relationship: A I /A A ≧ 1/50 wherein A I represents the height of the absorbance value of a composition containing a hematopoiesis inhibitor, as set forth in any of claims 1 through 5, at a wavelength of 280 nm in the gel filtration pattern of the solute in the dialyzate, and A A represents the height of the maximum absorbance value in the gel filtration pattern. The invention further relates to a dialysis membrane characterised in that the following relationship holds: A I /A A ≧ 1/50 wherein A I , represents the height of the absorbance value of a composition containing a hematopoiesis inhibitor, as set forth in any of claims 1 through 5, at a wavelength of 280 nm in the gel filtration pattern of the solute in the dialyzate, and A A represents the height of the maximum absorbance value in the gel filtration pattern. In addition, the invention relates to a pharmaceutical composition and an erythrocytosis remedy each containing the hematopoiesis inhibitor.

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NO-Patent Citations (3)

    Title
    KIDNEY INTERNATIONAL, vol. 29, no. 3, March 1986, pages 641-648, XP000602201 DELWICHE F. ET AL.: "Hematopoietic inhibitors in chronic renal failure: Lack of in vitro specificity"
    PROC SOC EXP BIOL MED 186 (1). 1987. 47-51, XP002017371 HOTTA T ET AL: "SELECTIVE INHIBITION OF ERYTHROPOIESIS BY SERA FROM PATIENTS WITH CHRONIC RENAL FAILURE."
    See also references of WO 9413702A1

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